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Mr. emosiderin (Hemosiderin) in a blood test - what is it? Deposits and localization of hemotiderin. Reasons for manifestation

Hemosiderin (Hemosiderin). The body's iron stores are stored in ferritin and hemosiderin. Ferritin is mainly found in the bone marrow, spleen and liver. Part of ferritin breaks down with the formation of an iron-containing protein-polysaccharide complex - hemosiderin. Normally, hemosiderin is not detected either in the blood or urine. Now imagine that as a result of a vessel injury or in the course of a reaction to a blood transfusion, or due to some disease (some forms of hemolytic anemia - for example, autoimmune ) , massive intravascular hemolysis (breakdown of red blood cells) occurs . Free hemoglobin will accumulate in the vascular bed. At a significant concentration of free hemoglobin in serum, it begins to penetrate into the kidneys. In the renal tubules, hemosiderin is formed from the iron of the decomposed hemoglobin.  

Both hemosiderin and hemoglobin, when accumulated in the tubules, enter the urine. So, the appearance of hemosiderin in urine is characteristic of intravascular hemolysis . Moreover, the importance of this test for diagnosis is emphasized by the fact that hemosiderin can be found in urine even in the absence of hemoglobin in it.

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