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Creatinine in the biochemical analysis of blood - regulations and or upgraded. What does it show?


Creatinine . Creatinine is a breakdown product of the protein creatine. Creatine is found primarily in the muscles, where it is involved in the energy-supplying reactions for muscle contraction. Creatinine is excreted in the urine. 

In blood serum, it is contained in the amount of 0.5-1 mg / dL , and normally these figures are constant. Their increase speaks, most often, of impaired renal function. When studying creatinine in daily urine, it is taken into account that its amount depends on the muscle mass of the body, and therefore the indicator is "tied" to body weight. 

Normal urine creatinine for men: 19–26 mg / kg of body weight / 24 h (milligrams per 1 kg of body weight in 24 hours); for women: 14–21 mg / kg of body weight / 24 h. If we write this amount not per kilogram of weight, but recalculate it for the absolute amount of released creatinine in 24 hours, then for the upper limit of the norm for a man weighing 60 kg we get the figure 26 x 60 = 1560 mg. An important indicator of advanced renal failure is creatinine clearance .    

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