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Blood test for a polypoproteins (Apo, Apolipoproteins). Apolipoprotein ratio


Apolipoproteins (Apo, Apolipoproteins). It was already mentioned above that fats in the blood are in the form of protein-fat compounds - lipoproteins. Determination of serum levels of total cholesterol and triglycerides, as well as separately fractions of low density lipoproteins (LDL - low density lipoproteins) and high density lipoproteins. (HDL - high density lipoproteins) allows you to judge the degree of risk of developing coronary heart disease. More on this below, when describing the corresponding tests.    

For now, we will only mention that an increased content of total cholesterol, triglycerides and low density lipoproteins (LDL) is regarded as a risk factor in the development of coronary heart disease, and an increase in serum high density lipoprotein (HDL), on the contrary, reduces the chances of progression of coronary heart disease. Serum apolipoprotein testing is a relatively new test. Apolipoproteins are the protein part of the lipoprotein complex. These protein formations are located on the surface of the complex and play an important role in lipoprotein conversion processes. Apolipoproteins are divided into four classes: "A", "B", "C", "E". There are varieties in the classes, for example "A I" (A one), "B 100", etc. Apolipoproteins of class "A" are mainly in the HDL fraction - high density lipoproteins (most of the proteins in this fraction are occupied by the apolipoprotein "AI "), And apolipoproteins of class" B " - in the fraction of low density lipoproteins (LDL). Now, if we go back a few lines up, remember that having more high-density lipoproteins (HDL) than normal means a decrease in the risk of complications of coronary heart disease, and a decrease in HDL indicates an increase in this risk. The opposite is the case with the assessment of the low density lipoprotein (LDL) fraction: their increase in serum indicates the likelihood of an unfavorable course of coronary heart disease.    

Accordingly, an increase in the amount of class "A" apolipoproteins is interpreted towards a good prognosis , and a decrease in them increases the risk of coronary heart disease . An increase in class B apolipoproteins is a risk factor for coronary heart disease.

Normal serum levels of apolipoprotein "A" are 90–155 mg / dL in men and 94–172 mg / dL in women; apolipoprotein "B" - 55-100 mg / dL in men and 45-110 mg / dL - in women.      

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